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A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with monogenic forms representing prototypes of the underlying molecular pathology and reproducing to variable degrees the sporadic forms of the disease. Using a patient-based in vitro model of PARK7-linked PD, we identified a U1-dependent splicing defect causing a drastic reduction in DJ-1 protein and, consequently, mitochondrial dysfunction. Targeting defective exon skipping with genetically engineered U1-snRNA recovered DJ-1 protein expression in neuronal precursor cells and differentiated neurons.

1 Januar 2020


Maria Biryukov
Article
History of the International Telecommunication Union (ITU). Transnational Techno-Diplomacy from the Telegraph to the Internet.

History of the International Telecommunication Union (ITU). Transnational Techno-Diplomacy from the Telegraph to the Internet.

This book focuses on the history of the International Telecommunication Union (ITU), from its origins in the mid-19th century to nowadays. ITU was the fi rst international organization ever and still plays a crucial role in managing global telecommunications today.

1 Januar 2020


Andreas Fickers
  • Public history
  • Contemporary history of Luxembourg
  • Contemporary history of Europe
  • Digital history & historiography
Article
Illyrer und Dakerrezeption in Albanien und Rumänien. Mythenbildung und faktische Probleme.

Illyrer und Dakerrezeption in Albanien und Rumänien. Mythenbildung und faktische Probleme.

1 Januar 2020


Sam Mersch
Article
Einleitung: Die belgische Militärpräsenz in Deutschland (1945-2005). Umrisse eines Forschungsfelds

Einleitung: Die belgische Militärpräsenz in Deutschland (1945-2005). Umrisse eines Forschungsfelds

his volume analyses Belgian garrisons in the Rhineland and Westphalia after the Second World War. They are analysed as contact zones that clearly indicate the political, economic, societal and military consequences of European integration for daily coexistence. The book’s contributions focus on mechanisms and catalysts of entanglement, dissolution and coexistence in local spaces, which did not relocate transnational contacts within Europe to national borderlines, but permanently (re-) configured them in a confined space. How do transnational contacts take place?

1 Januar 2020


Christoph Brüll
Article
On the diachrony of giusto? (right?) in Italian: A new discoursivization

On the diachrony of giusto? (right?) in Italian: A new discoursivization

In Italian, the adjective giusto (‘right’) has performed the discourse function of response marker since at least 1613 (DELI 2008: 671). In this paper, I argue that the adjective has recently undertaken a new process of discoursivization, defined as the diachronic process that ends in discourse (Ocampo 2006: 317). In particular, I maintain that giusto may also serve the function of invariant tag (Andersen 2001), a linguistic item appended to a statement for the purpose of seeking mutual agreement, verification or corroboration of a claim (Millar and Brown 1979).

1 Januar 2020


Lorella Viola
  • Digital history & historiography
Article
How to read the 52.000 pages of the British Journal of Psychiatry? A collaborative approach to source exploration

How to read the 52.000 pages of the British Journal of Psychiatry? A collaborative approach to source exploration

Historians are confronted with an overabundance of sources that require new perspectives and tools to make use of large-scale corpora. Based on a use case from the history of psychiatry this paper describes the work of an interdisciplinary team to tackle these challenges by combining different NLP tools with new visual interfaces that foster the exploration of the corpus. The paper highlights several research challenges in the preparation and processing of the corpus and sketches new insights for historical research that were gathered due to the use of the tools.

1 Januar 2020


Eva Andersen, Lars Wieneke, Maria Biryukov
  • Contemporary history of Europe
  • Digital history & historiography
Article
Beyond Digitizing

Beyond Digitizing

1 Januar 2020


Sean Takats
  • Digital history & historiography
Article
Zwischen neuem „Hör-Gefühl“ und „Psychoterror“: Die Debatte über die emotionale Wirkung der Kunstkopf-Stereophonie im Hörspiel der 1970er Jahre

Zwischen neuem „Hör-Gefühl“ und „Psychoterror“: Die Debatte über die emotionale Wirkung der Kunstkopf-Stereophonie im Hörspiel der 1970er Jahre

1 Januar 2020


Stefan Krebs
  • Public history
Article
Material Cultures of Psychiatry

Material Cultures of Psychiatry

1 Januar 2020


Benoît Majerus
Article
Surveillance, indépendance et intégrité

Surveillance, indépendance et intégrité

1 Januar 2020


Benoît Majerus
Article
Using environmental predictive settlement choice models as input data for settlement pattern simulations

Using environmental predictive settlement choice models as input data for settlement pattern simulations

Inductive models of archaeological site locations have been successfully used for predicting archaeological potential of places in landscapes. These models are mostly based on currently observable environmental information. To reduce environmental determinism and increase both explanatory and predictive power several variables like visibility of locations have been interpreted as social factors of settlement locations.

1 Januar 2020


Kaarel Sikk
  • Digital history & historiography
Article
Review: Angela Griessenböck, Von Heilung, Pflege und Verwahrung. Zur Geschichte der Landesirrenanstalt in Hall in Tirol und ihrer Patientinnen und Patienten (1882–1918)

Review: Angela Griessenböck, Von Heilung, Pflege und Verwahrung. Zur Geschichte der Landesirrenanstalt in Hall in Tirol und ihrer Patientinnen und Patienten (1882–1918)

1 Januar 2020


Benoît Majerus
Article
Visualising changes in the construction of meaning with Word Vector Space: A Digital Humanities Approach

Visualising changes in the construction of meaning with Word Vector Space: A Digital Humanities Approach

1 Januar 2020


Lorella Viola
  • Digital history & historiography
Article
CVH Malach – Centrum vizuální historie Konference a workshop o novém přístupu a využití video databáze Fortunoff

CVH Malach – Centrum vizuální historie Konference a workshop o novém přístupu a využití video databáze Fortunoff

On May 18, I took part in a very interesting workshop organized by the Malach Centre for Visual History at the Faculty of Mathematics and Physics of the Charles University in Prague. This exceptional association provides local access to the extensive digital archives of the USC Shoah Foundation - the Institute for Visual history and Education (USC), the Refugee Voices archive of the Association of Jewish Refugees and the testimony collection of the Jewish Holocaust Centre in Melbourne.

1 Januar 2020


Jakub Bronec
  • Contemporary history of Luxembourg
  • Contemporary history of Europe
  • Digital history & historiography
Article
Making Europe - Looking at the history of Europe in the long twentieth century through the lens of technology

Making Europe - Looking at the history of Europe in the long twentieth century through the lens of technology

Science and technology are at the very heart of the European project. But how to write a history of Europe in the making when using technology as an actor category and lens of analysis? This is the driving narrative behind Making Europe: Technology and Transformations (1850-2000) – a sixvolume series on the history of Europe in the «long twentieth century»1. All volumes in the series are co-authored by two or three authors and are the result of an intense debate and discussion amongst all people involved in this collective endeavor.

1 Januar 2020


Andreas Fickers
  • Public history
  • Contemporary history of Luxembourg
  • Contemporary history of Europe
  • Digital history & historiography
Article
Too small to be of interest, too large to grasp? Histories of the Luxembourg financial centre

Too small to be of interest, too large to grasp? Histories of the Luxembourg financial centre

The importance of smaller financial centres in international capitalism has recently been highlighted by a number of ‘leaks’. Yet such public attention stands in contrast to the paucity of historiographical research on these relatively new centres. To this regard, Luxembourg provides an interesting case study. While identified as a ‘global specialist’ by the Global Financial Centres Index, the genealogy of how it came to achieve this status remains largely under-researched.

1 Januar 2020


Benoît Majerus
Article
Special Issue: The Dissolution of the Austro-Hungarian Monarchy: Border Making and its Consequences.

Special Issue: The Dissolution of the Austro-Hungarian Monarchy: Border Making and its Consequences.

1 Januar 2020


Machteld Venken
  • Contemporary history of Luxembourg
  • Contemporary history of Europe
Article
Kateřina Čapková – David Rechter, eds., Židé, nebo Němci? Německy mluvící Židé v poválečném Československu, Polsku a Německu [Jews or Germans? German-Speaking Jews in Czechoslovakia, Poland and Germany after World War II]

Kateřina Čapková – David Rechter, eds., Židé, nebo Němci? Německy mluvící Židé v poválečném Československu, Polsku a Německu [Jews or Germans? German-Speaking Jews in Czechoslovakia, Poland and Germany after World War II]

The edited book ‘Jews or Germans?’ seeks to explore the post-war expulsion of the German minority, which did not involve only Nazi adherents and ideologists. To a certain extent, the entire process of displacement should not be apprehended solely from national or ethnic perspectives with clearly defined categories. In this sense, the project aims to problematize the established view of Jewish emigration history.

1 Januar 2020


Jakub Bronec
  • Contemporary history of Luxembourg
  • Contemporary history of Europe
  • Digital history & historiography
Article
The Rise of Television: Institutionalization and the Framing of National Audiences

The Rise of Television: Institutionalization and the Framing of National Audiences

1 Januar 2020


Andreas Fickers
  • Public history
  • Contemporary history of Luxembourg
  • Contemporary history of Europe
  • Digital history & historiography
Article
Machine Learning to Geographically Enrich Understudied Sources: A Conceptual Approach

Machine Learning to Geographically Enrich Understudied Sources: A Conceptual Approach

This paper discusses the added value of applying machine learning (ML) to contextually enrich digital collections. In this study, we employed ML as a method to geographically enrich historical datasets. Specifically, we used a sequence tagging tool (Riedl and Padó 2018) which implements TensorFlow to perform NER on a corpus of historical immigrant newspapers. Afterwards, the entities were extracted and geocoded. The aim was to prepare large quantities of unstructured data for a conceptual historical analysis of geographical references.

1 Januar 2020


Lorella Viola
  • Digital history & historiography
Article

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